Differential mechanisms affecting weight loss and weight loss maintenance

Nature Metabolism volume 5, pages 1266–1274 (2023)Cite this article

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In most lifestyle, pharmacological and surgical interventions, weight loss occurs over an approximately 6- to 9-month period and is followed by a weight plateau and then weight regain. Overall, only about 15% of individuals can sustain a 10% or greater non-surgical, non-pharmacological, weight loss. A key question is the degree to which the genotypes, phenotypes and environmental correlates of success in weight loss and weight loss maintenance are continuous or dichotomous. This Perspective is a comparison of the interactions of weight loss and maintenance with genetic, behavioural, physiological and environmental homeostatic systems and a discussion of the implications of these findings for research in, and treatment of, obesity. Data suggest that weight loss and weight loss maintenance are physiologically and psychologically different in many ways. Consequently, individuals may require different interventions designed for temporarily sustaining a negative energy balance during weight loss versus permanently maintaining energy balance after weight loss.

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These studies were supported, in part, by grants from the National Institutes of Health (UL1 TR00040 to M.R.), the National Institute of Diabetes and Digestive and Kidney Diseases (R01 30583 and R01 64773 to M.R., R01 DK130851 to G.F.) and the National Heart, Lung, and Blood Institute (1UG3 H163121 to G.F.).

Columbia University Irving Medical Center, Departments of Pediatrics and Medicine, Division of Molecular Genetics and the Irving Center for Clinical and Translational Research (MR), New York, NY, USA

Michael Rosenbaum

WW International, Perelman School of Medicine at the University of Pennsylvania, Department of Psychiatry, Weight and Eating Disorders Program (GF), New York, NY, USA

Gary Foster

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The authors contributed equally to the writing of this manuscript.

Correspondence to Michael Rosenbaum.

M.R. declares no competing interests. G.F. is an employee and shareholder at WW International.

Nature Metabolism thanks Michael Lean and Steven Heymsfield for their contribution to the peer review of this work. Primary Handling Editor: Ashley Castellanos-Jankiewicz, in collaboration with the Nature Metabolism team.

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Rosenbaum, M., Foster, G. Differential mechanisms affecting weight loss and weight loss maintenance. Nat Metab 5, 1266–1274 (2023). https://doi.org/10.1038/s42255-023-00864-1

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Received: 23 September 2022

Accepted: 13 July 2023

Published: 23 August 2023

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DOI: https://doi.org/10.1038/s42255-023-00864-1

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